Locus is a lili'tu: half-human, half-succubus. She is also the Locus of Life and Death.
A warrior-daughter of the Spider Mother.
Nuestra Señora de la Santa Muerte is a female folk saint venerated primarily in Mexico and the United States.
Silk is Locus' aunt and sword instructor.
John Dee, Charles Dearing, Milenius...and those are just his human aliases. Dee is Locus' grandfather and was the first lili'tu. He is also a Necromancer, but please don't hold that against him. He's really a nice man.
Cesar is a Colonel in Cuerpo de Fuerzas Especiales de México (Mexico's Special Forces).
Isaac is Locus' father. He's dead now, but that doesn't stop him from having fun.
Eden is Locus' mother. She's dead, and spending her time in the Realms of the Dead having fun with Isaac and being the Goddess of Spring.
The Goddess of Blades is the goddess who was mutilated and imprisoned in Xel'Duum's Raath. Locus freed her with Una'to Xel in Locus #19.
Spook is Locus' uncle and the one who taught her to hunt.
Slip is Spook and Silk's infant daughter. She shouldn't have been possible, but Eden is also the Goddess of Fertility, and has a slight mischevious streak.